<![CDATA[Scipedia: Collection of Biomedical Science]]>
/sj/biomedical
/public/Pratim-Roy_2016aThu, 20 Oct 2016 16:35:18 +0200
/public/Pratim-Roy_2016a
<![CDATA[Contraceptive behaviour in North India]]>Scipedia content/public/Hjelmeland_Zhang_2016aThu, 20 Oct 2016 16:35:14 +0200
/public/Hjelmeland_Zhang_2016a
<![CDATA[Metabolic, autophagic, and mitophagic activities in cancer initiation and progression]]>Cancer is a complex disease marked by uncontrolled cell growth and invasion. These processes are driven by the accumulation of genetic and epigenetic alterations that promote cancer initiation and progression. Contributing to genome changes are the regulation of oxidative stress and reactive species-induced damage to molecules and organelles. Redox regulation, metabolic plasticity, autophagy, and mitophagy play important and interactive roles in cancer hallmarks including sustained proliferation, activated invasion, and replicative immortality. However, the impact of these processes can differ depending on the signaling pathways altered in cancer, tumor type, tumor stage, and/or the differentiation state. Here, we highlight some of the representative studies on the impact of oxidative and nitrosative activities, mitochondrial bioenergetics, metabolism, and autophagy and mitophagy in the context of tumorigenesis. We discuss the implications of these processes for cellular activities in cancer for anti-cancer-based therapeutics.
]]>Scipedia content/public/Chen_2016aThu, 20 Oct 2016 16:35:12 +0200
/public/Chen_2016a
<![CDATA[Honoring antiparasitics: The 2015 Nobel Prize in Physiology or Medicine]]>Protozoa and helminths are the two main groups that cause parasitic diseases with a broad spectrum of clinical symptoms. Protozoa are unicellular organisms like the malaria parasite Plasmodium, which is responsible for the majority of deaths associated with parasitic infections. Helminths are alternative parasites that can produce debilitating diseases in hosts, some of which result in chronic infections. The discovery of effective therapeutic drugs is the key to improving health in regions of poverty and poor sanitation where these parasites usually occur. It is very encouraging that the 2015 Nobel Prize in Physiology or Medicine was awarded to Youyou Tu as well as William C. Campbell and Satoshi ?mura for their considerable contributions in discovering artemisinin and avermectin, respectively. Both drugs revolutionized therapies for filariasis and malaria, significantly reducing by large percentages their morbidity and mortality.
]]>Scipedia content/public/Choudhary_2016aThu, 20 Oct 2016 16:35:09 +0200
/public/Choudhary_2016a
<![CDATA[Meeting the unmet needs of family planning]]>Scipedia content/public/Akhondzadeh_et_al._2016aThu, 20 Oct 2016 16:35:05 +0200
/public/Akhondzadeh_et_al._2016a
<![CDATA[A comparison between the effects of propofol–fentanyl with propofol–ketamine for sedation in patients undergoing endoscopic retrograde cholangiopancreatography outside the operating room]]>The efficient and secure techniques of anesthesia and sedation have always been needed for. One of these procedures is endoscopic retrograde cholangiopancreatography (ERCP), due to its painfulness and long duration, has high sensitivity. We compare the effects of propofol–fentanyl (PF) with propofol–ketamine (PK) to sedate patients undergoing ERCP. In this clinical trial, patients were divided into two groups of 49 people. A group?received a pharmaceutical combination of PK, and another group received a pharmaceutical combination of PF. Vital signs of patients, Ramsey Sedation Score, and pain of patients were assessed. The total dosage of used propofol was also recorded. There was no significant difference seen in the patients' hemodynamic characteristics in both groups. Pain at the end of surgery and an hour after it in the PK group was less that was?not statistically significant. By Ramsey Sedation Score also significant differences were not seen between groups (p?=?0.68). By using total dose of propofol used also a significant difference?was not observed between the two groups (p?=?0.36). Rate of apnea in PK group was 32% and in the PF group was 63%, which this difference was statistically significant (p?
]]>Scipedia content/public/Louise-Walton_2016aThu, 20 Oct 2016 16:35:02 +0200
/public/Louise-Walton_2016a
<![CDATA[The dual role of ROS, antioxidants and autophagy in cancer]]>In this issue of the Biomedical Journal, we highlight a review revealing that the effect of autophagy, reactive oxygen species, and antioxidants in cancer may be a question of timing and context. We also discuss original research showing that the prevalence of cleft lip with or without palate in Taiwan has declined over the past 20 years, and what this might mean in terms of trends in abortion. Finally, we also learn about risk factors for recurrent hospital-acquired infection with multi-drug resistant bacteria, and the value of dental screening for patients with tinnitus.
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The airplane was flattening out! There was now at Grant the prospect of a girl, and for days ahead the bachelors had planned about her. She was Landor's ward,—it was news to them that he had a ward, for he was not given to confidences,—and she was going to visit the wife of his captain, Mrs. Campbell. When they asked questions, Landor said she was eighteen years old, and that her name was Cabot, and that as he had not seen her for ten years he did not know whether she were pretty or not. But the vagueness surrounding her was rather attractive than otherwise, on the whole. It was not even known when she would arrive. There was no railroad to[Pg 14] Arizona. From Kansas she would have to travel by ambulance with the troops which were changing station. Cairness said to himself that she was regal, and acknowledged her most formal welcome with an ease he had fancied among the arts he had long since lost. "Where are you from?' "When the boys got back they found them smart Alecks, Bob Walsh and Andy Sweeney, waiting for 'em, and they consoled 'em, saying, That's just the way with that old bull-head. Never'll take no good advice from nobody about running' the company. Thinks he knows it all. You see how he runs the company. He haint got the addresses o' half his men this minnit, and don't know where they are. That's the reason so many o' our letters from home, and the good things they send us, never reach us. He ought to keep a regler directory, same as in the other companies.'" "We would be alone," Cadnan said simply. "No master would feed us. We would die." "Nonsense," said Reuben, resenting her manner. Rose smiled to herself, and when she next had occasion to punish Reuben, invited his drover to a cup of tea. "No—and mark you, nor am I. It 'ud have been worse for me if I'd stayed. I'm miserable in a different way from what I was there—somehow the life's easier. I'm not happy, but I'm jolly. I'm not good, but I'm pleasant-like. It's all a change for the better. See?" "She was my mother!" said the mourner, rising. HoME成人搞逼在线视频
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